The American Genealogical-Biographical Index (described in Massachusetts Genealogy) cites many references to biographies of Massachusetts residents. In addition, two comprehensive biographical encyclopedias are:
The American Historical Society. Encyclopedia of Massachusetts, Biographical-Genealogical. 13 vols. New York, NY: The American Historical Society, ca. 1916. (FHL book 974.4 D3e; fiche 6046891.) The Family History Library has volumes 1–4, 6, and 10–13 only.
Eliot, Samuel Atkins. Biographical History of Massachusetts. 10 vols. Boston, Massachusetts: Massachusetts Biographical Society, 1911-18. (FHL book 974.4 D3eL.)
Biographical sketches of many Plymouth Colony residents, including those who came on the Mayflower, are in:
Stratton, Eugene Aubrey. Plymouth Colony: Its History and People, 1620-1691. Salt Lake City, Utah: Ancestry, 1986. (FHL book 974.4 H2s.)
See Massachusetts Genealogy for additional references to biographies and genealogies for Massachusetts ancestors.
A Genealogical Dictionaryof the First Settlers of New England Before 1692: http://www.usgennet.org/usa/topic/newengland/savage/
U.S. Biographies Project: Massachusetts - http://www.rootsweb.com/~mabiog/
Biographies and information on Mayflower passengers can be found at http://www.mayflowerhistory.com/Passengers/passengers.php